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PMID: 38005352 148

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As an anti-fibrotic compound, AST inhibits fibroblast activation and the EMT process through multiple mechanisms and shows promising therapeutic prospects in treating renal and pulmonary fibrosis

Structural alignment of the ligand-binding pockets for the two agonists and the antagonist C12 suggests that agonist-binding causes a subtle change in the salt bridge between E124 3.33 and R283 6.55 (Fig