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After 24 weeks, the evinacumab group exhibited significant (47.1%) reduction in LDL-C levels (vs baseline concentrations), whereas the placebo group showed minor (1.9%) increase.39 Evinacumab serves to enhance an EL-dependent pathway, bringing about reductions in lipid content in VLDL and particle size and generating remnant particles that are efficiently cleared from the circulation.40 Vupanorsen (Pfizer Inc., New York, NY, USA) is another GalNAc-conjugated ASO targeting hepatic ANGPTL3 mRNA

Taylor, J., Eghtesadi, S., Points, L., Liu, T

FDA approves Afrezza to treat diabetes

More mitochondria per cell translates to greater oxidative capacity and reduced fatigue

In October 2019, the United States Food and Drug Administration (FDA) approved MT1 under the brand name Scenesse for increasing sunlight tolerance and alleviating pain from ultraviolet (UV) light exposure in patients with erythropoietic protoporphyria (EPP) [4]

PMID: 28906340 Beighton P, De Paepe A, Steinmann B, Tsipouras P, Wenstrup RJ