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Eichler, K., Buchet, A., Lemke, R., Kleber, H

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While 3-oxoLCA inhibited Th17 cell differentiation through binding to its main transcription factor, RORt, isoalloLCA upregulates Treg cell differentiation through the production of mitoROS, which increases FoxP3 expression ( (C) Using murine models and in vitro studies with bacteria derived from humans, several bacterial genera were identified as producers of 3-oxoLCA, including Gordonibacter pamelaeae P7-E3, Eggerthella lenta P7-G7, Raoultibacter massiliensis P7- A2, Collinsella intestinalis P8-C1, Adlercreutzia equolifaciens P11-C8 , and Clostridium citroniae P2-B6

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Among the former, acute intermittent porphyria is the most common, whereas the most prevalent form of cutaneous porphyria (and at the same time the most common overall) is porphyria cutanea tarda, affecting about 510 per 100,000 people