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Other established risk factors include: Hyperlipidemia Metabolic syndrome Obesity Atrial fibrillation Chronic kidney disease Sedentary lifestyle Sleep disorders, particularly obstructive sleep apnea Sleep disorders may contribute to CSVD through intermittent hypoxia, sympathetic activation, endothelial dysfunction, and impaired glymphatic clearance

Mechanisms of central hypogonadism

They provided updated insights into the molecular biology of spermatogenesis, underlining the role of the molecular factors involved in oocyte fertilization and embryo growth that are produced during spermatogenesis and carried out by the sperm cell

Decision between mitophagy and apoptosis by Parkin via VDAC1 ubiquitination

Four PARPi (olaparib, rucaparib, niraparib, and talazoparib) are currently approved by the US Food and Drug Administration (FDA), and additional PARPi are in clinical development [5]