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4-HNE is a major end product of lipid peroxidation that is present in normal human plasma at concentrations ranging from 0.1M to 1.4M and this can increase more than 10 folds during oxidative stress in vivo [84]

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PMID 12168806

High blood pressure (hypertension) is a common condition that affects about one in three adults in the United States ( Many people use natural therapies to help lower their blood pressure either in conjunction with prescription medications or to avoid medications altogether

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Curcumin was included as a reference compound
