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Mechanisms of cisplatin ototoxicity and progress in otoprotection
The results uncover imbalances that may be silently speeding up aging
R., El-Refaie, W
While it is not classified as a controlled substance, it is also not approved by any major regulatory agencyincluding the FDA , EMA , or TGA for human use
The trans disposition of the two chloride ligands in trans -diamminedichloroplatinum(II) renders them kinetically labile in comparison to those of the cis isomer, and thus susceptible to undesirable side reactions with extra- and intra-cellular biomolecules
PI3K/AKT Signal Pathway: A Target of Natural Products in the Prevention and Treatment of Alzheimer's Disease and Parkinson's Disease. Frontiers in Pharmacology 12: 648636
