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Collectively, these findings position Vitamin D not merely as a passive fat-soluble micronutrient, but as an integrative regulator of skin architecture, immunity, and metabolism, with pronounced potential to restore epidermal ecosystem balance under inflammatory stress

This review also highlighted shared resistance mechanisms across treatment modalities and discussed emerging strategies to overcome these barriers

Tanoli T, Yue P, Yablonskiy D, Schonfeld G (2004) Fatty liver in familial hypobetalipoproteinemia: roles of the APOB defects, intra-abdominal adipose tissue, and insulin sensitivity

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