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This is consistent with our observation that persister cells have downregulated expression of glutathione and NADPH biosynthesis genes (Extended Data Table 2)

2024;30:e14455

Reduced levels of oxygen and presence of an inflammation cytokine milieu contribute to the tissue damage (171, 172), and stimulate IFN production in effector cells under Th17-driving conditions, suggesting a switch towards Th1 responses ( Low oxygen levels stabilize HIF-1 disrupting mitochondrial function and increasing ROS impairing metabolic fitness in activated T cells (173)

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After de-paraffinization and rehydration, sections underwent a heat-induced epitope retrieval by microwave heating in 0.1 M TRIS hydrochloride (HCl) (pH 9.0) for 15 min

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