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Is the breakout after microneedling purging or a real breakout

Any interpretation beyond laboratory research is speculative

Moreover, senescence cells secrete many bioactive molecules collectively termed the senescence-associated secretory phenotype (SASP), which can induce chronic inflammation, alter tissue architecture, and promote tumorigenesis through paracrine signaling

T.et al (2022)

In most cases, failures will initiate at a point of weakness in wood under tension, on the outside surface of the wood, traveling from the point of initial failure

[1] It is investigated for its potential role in nitric oxide pathway modulation, growth factor signaling, and extracellular matrix remodeling