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Apoptosis, pyroptosis, and ferroptosis conspiringly induce immunosuppressive hepatocellular carcinoma microenvironment and gammadelta T-cell imbalance

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One speculation is that although adipocytes have reduced GPX4, adipocytes may be similar to some tumor cells, which still have a high level of GSH in their cells, so that although adipocytes are in an overall oxidative stress condition, the remaining GPX4 from GSH is still needed to neutralize large amounts of ROS and remove some of the lipid peroxides, resulting in differentiated adipocytes that are not or less affected by ferroptosis (81)