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[DOI] [PubMed] [Google Scholar] 88.Buettner G.R., Jurkiewicz B.A

Although reduced protein stability promotes amyloid formation, it alone cannot fully explain disease onset, as pathology is also influenced by external factors

Topical applications may have limited value depending on whether the nutrient (or compound) is well absorbed through the skin, whether it has local or systemic effects, and whether it has acute or longer term effects
doi: 10.1038/s41587-022-01419-7 83 TongH.WangX.LiuY.LiuN.LiY.LuoJ.et al

The term "reduced" refers to the chemical state of the molecule
Briefly, sgRNAs were identified on the website of Prof