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These findings implicate cysteine metabolism as a critical regulator of ferroptosis susceptibility and suggest that metabolic vulnerabilities in TNBC could be exploited to enhance treatment efficacy (74)

From the analysis of the structure-activity relationship (SAR) studies, the pomalidomide-based PROTACs showed better results than the lenalidomide-based or VHL-based PROTACs

However, a much repeated criticism of studies of MSG taken without food is that the characteristic strong flavor of MSG is difficult to mask, unblinding the subjects to its identity and potentially leading to bias. Even in people who self-identify as MSG sensitive, studies have failed to provide reproducible evidence of an MSG effect. The authors of the largest and most comprehensive of such studies concluded that large doses of MSG given without food may elicit more symptoms than a placebo in individuals who believe that they react adversely to MSG

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doi: 10.1007/s00383-006-1721-9

Mitochondrial dynamics controls T cell fate through metabolic programming