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A phase III clinical trial of Catena in the United States was reported not to have a statistically significant benefit amongst participants, although the study did indicate that Catena was safe and well-tolerated in study participants (Lynch et al., 2010)
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The mitochondrial OCR was measured at baseline and following sequential addition of 1 M oligomycin (ATP synthase inhibitor), 4 M carbonyl cyanide 4-FCCP) (a mitochondrial uncoupler, and 0.5 M rotenone (Complex I inhibitor) plus 0.5 M antimycin A (Complex III inhibitor) 32,35,38
Scientific reports from in vitro and in vivo have linked aspartame to many detrimental health issues
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