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(3) studies published in peer-reviewed journals
The G protein dissociates and one subunit interacts with and activates an enzyme - phospholipase C - which cleaves the phospho-head group from a membrane phospholipid - phosphatidyl inositol - 4,5-bisphosphate (PIP2) into two second messengers - diacylglyerol and inositol trisphosphate (IP3)

[DOI] [PubMed] [Google Scholar] 24.Cruciani R.A., et al
An adenovirus coding CRP (Ad-CRP) and a control blank adenovirus (Ad-Null) were then constructed using the AdEasy system (Stratagene, La Jolla, CA)