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Consequently, this heightened metabolic rate not only underscores the aggressive nature of the disease but also offers potential therapeutic targets for disrupting tumor growth ( The significant abundance of SLC7A11 suggests its potential as a promising target for tumor therapy ( + T cells, which release IFN- to enhance tumor cell ferroptosis via PD-L1 inhibition ( Given the pivotal role of SLC7A11 in cancer treatment, this paper provides an overview of its structure and biological functions, as well as its involvement in oxidative stress, tumor metabolism, immune modulation, and cell death ( Figure 1 )

Functional properties and genomics of glucose transporters

Statements Author contributions HQ: Conceptualization, Writing original draft, Writing review & editing

Sousa et al., 2000

These demonstrated that the administration of 3 mg/kg of MK-0677 resulted in an 11.6% increase in food intake and 64% lean mass gain in the mice compared with the vehicle (control) group

10.2147/DDDT.S149298 328 ZhangH.YinG.JiangH.ZhangC