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Epigenetic inactivation of SOX30 is associated with male infertility and offers a therapy target for non-obstructive azoospermia

In the split-Ugi condensation, the same five isocyanide derivatives underwent reaction with the aldehyde and the acid-ligand, in the presence of piperazine as the symmetric amine 178

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The cysteine-penicillamine (Cys-Pen) bridges introduce steric hindrance via gem-dimethyl substituents on penicillamine, thus enhancing reductive stability while preserving native disulfide bond geometry (Li et al., 2024a