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Akkermansia muciniphila mediates negative effects of IFNgamma on glucose metabolism

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Elevated GPX4 also attenuates NF-B activation (208) and suppresses fibroblast IL-6 release (209), mitigating fibrosis

The defection of mitophagy will lead to the accumulation of dysfunctional mitochondria, resulting in the leakage of Cytc into the cytoplasm to induce the activation of the caspase signaling pathway, and contribute to cell death (Sinha et al., 2013