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It works by binding to membrane-bound HDM-2, forming pores in the cancer cell membrane, and causing rapid cell death through necrosis, while sparing normal cells

More recently, it has been suggested that individuals with pre-existing comorbidities such as metabolic syndrome and lung, heart and kidney disease are at a higher risk of developing a serious infection

& Bartizal, K

doi: 10.1007/s00424-010-0834-0

SIRT3 promotes the transcription-activating activity of FOXO3A by decreasing the latters acetylation and phosphorylation, which in turn induces the expression of genes encoding antioxidant enzymes 34

In addition to the role mentioned above in the process of oxidative stress, the GPX family also plays a unique role in tumor development ( Statements Author contributions All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication