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[DOI] [PMC free article] [PubMed] [Google Scholar] Dai SH, Li JF, Feng JB, Li RJ, Li CB, Li Z, Zhang Y, Li DQ

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This modification allows the peptide to bind to amylin receptor subtypes 1 and 3 in the brain, specifically in the area postrema of the hindbrain, producing sustained appetite reduction without the peaks and valleys that come with shorter-acting compounds

We also tested the cell toxicity of Hst in ihLECs ranging from 25 to 400 mM (Fig