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10.1016/j.tig.2019.03.005 61 MelliouE.ChinouI

For instance, in chimeric human cerebral organoids (chCOs), astrocytes and neurons carrying the APOE4 genotype could jointly promote tau phosphorylation in neurons, closely linked to the role of APOE4 in increasing cholesterol levels and lipid droplet content, suggesting that APOE4 may affect tau phosphorylation in AD by influencing lipid metabolism

Prognostic Factors in Surgical Patients with Sporadic Medullary Thyroid Cancer

In particular, USP22 raised GSH content and reduced the occurrence of ferroptosis in cardiomyocytes by activating the Sirt1-p53/SLC7A11 axis [252]

[DOI] [PubMed] [Google Scholar] 59.Hochgrfe K., Sydow A., Matenia D., Cadinu D., Knen S., Petrova O., Pickhardt M., Goll P., Morellini F., Mandelkow E., et al

Stress can even contribute to autoimmunity