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Mao, Y., Tokudome, T., Kishimoto, I., Otani, K., Miyazato, M., & Kangawa, K

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5-Amino-1-methylquinolinium iodide is the lead first-in-class small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) an enzyme overexpressed in white adipose tissue of obese individuals where it consumes the methyl-donor pool and depletes tissue NAD

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Some individuals may require long-term treatment to manage chronic conditions affecting B12 absorption or metabolism
