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Students t test (two-tailed) was applied to compare difference between two groups

Cell 73 , 11971206 ( 1993)

It is known that IGF1R can activate two canonical pathwaysPI3K/AKT pathway and the extracellular signal-regulated kinase (ERK) pathway 22

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Expression levels of genes were Primer pairs used for the qRT-PCR analysis are listed in Table 3

For example, posttranslational modifications such as methylation, phosphorylation and ubiquitinylation can strongly influence the enzymatic function of a protein 10