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One extensively studied polymorphism is rs2234694 (+35A/C), situated at the junction site between the intron and exon 3 (Ben Anes et al., 2019

TABLE 7 Summary of clinical trials investigating curcumin formulations in different types of cancer

Mamula with Ranger who became cancer-free after his metastatic osteosarcoma was treated with the vaccine

This represents approximately 3-fold improved local delivery and demonstrates that formulation significantly impacts outcomes

Thus, triptolide derivatives can overcome the solubility and cytotoxicity limitations of the parent compound, enhancing bioavailability, targeting specificity, and reducing toxicity, while also providing innovative therapeutic modalities such as photodynamic therapy and optical imaging capabilities for improved cancer treatment outcomes

In medicine, it supports liver detoxification and immune function