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10.1007/BF00404074 Diabetologia 58 HammermanM

doi: 10.1016/j.redox.2020.101619 48 SakajiriTYamamuraTKikuchiTYajimaH

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Glia 68:18101823

373 FTO is upregulated in macrophages loaded with ox-LDL, which enhances cholesterol efflux via motivating AMPK/ACC phosphorylation to promote ABCA1/G1-mediated efflux, and attenuates cholesterol ester accumulation through restricting PPAR to reduce CD36 expression

Additional evidence suggests it plays an important role in immune surveillance and inflammatory cell trafficking, while also allowing for communication between the local tissue environment and the more luminally located smooth muscle and endothelial cells (178, 179)