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Management generally involves levothyroxine replacement therapy, complemented in some cases by dietary optimization and micronutrient supplementation

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Over time, researchers noticed that levels of GHK-Cu tend to decrease with age, which led to further interest in how it relates to skin appearance

*Correspondence: Mohammed Alsafran, [email protected] This article was submitted to Plant Nutrition, a section of the journal Frontiers in Plant Science Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

What they do not have is a body of controlled evidence showing that injecting them causes clinically significant weight loss independent of diet, exercise, and the rest of a supervised program

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