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The dose for methotrexate starts at 15mg weekly with SC formulations having better bioavailability compared with oral, particularly at higher doses, owing to malabsorption[1]

1 2 "Regulation of the Hypothalamic-Pituitary-Adrenocortical Stress Response"

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The screened features included three pathways associated with Parkinson's disease: neuroinflammation (RTCA), oxidative stress homeostasis (GCLC, oleamide), and metabolic regulation (prostaglandin AI ethyl ester, ADAMTSLA, MGP)