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Author Contributions Muhammad Tayyab Arshad: methodology (equal), writing original draft (equal)

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Since 4F2hc is constitutively expressed on the membrane and may be coupled not only with xCT, but also with other partners to elicit different transporter activities [51], the expression of xCT is used as an indicator of Sxc activity

Jankovic J, Goodman I, Safirstein B, et al

Astrocytes are also involved in the recruitment of inflammatory cells to the site of injury, through the formation of a glial scar termed reactive astrogliosis which involves activation and proliferation of astrocytes to limit extending damage ( Bmal1 , shown through activation and increased inflammatory gene expression using an astrocyte specific Bmal1 knockout ( Bmal1 knockouts in astrocyte cultures have reported reduced actin-binding protein cortactin and impaired actin stress fiber formation ( Other immune cell populations that are involved in regulating the progression of ischemic injury are neutrophils, macrophages, and T-cells ( Bmal1 expression (Scheiermann et al., 2013)