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Assessing OS biomarkers, including ROS levels, total antioxidant capacity (TAC), lipid peroxidation products and DNA fragmentation, is critical for detecting redox imbalances

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A large number of antioxidant based strategies focusing on ascorbic acid, deferoxamine, cucurmin etc has been investigated for management of the PD symptoms but without any translatable benefits 47,48

136 Melatonin is also used to treat sleep disturbances and insomnias caused by aging, as well as pathological conditions including COPD

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doi: 10.1038/s41579-022-00846-2 22 DefelipeJ.FarinasI