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Our review aims to combine existing evidence on pathophysiological mechanisms that connect PCOS with pain through hormonal, metabolic, inflammatory, and oxidative factors as well as evaluates its clinical manifestations and treatment methods alongside research models

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Unlike BPC-157, TB-500, and GHK-Cu, which remain investigational, teriparatide (PTH 1-34) and abaloparatide have received FDA approval for treating osteoporosis and are prescribed to patients worldwide

GHK-Cu longevity depends heavily on storage conditions, with room temperature exposure limited to 1-2 weeks for lyophilized material

Current evidence suggests earlier surgical intervention improves axonal survival post-injury and addresses potential issues such as retraction and fibrosis