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CF is defined as an imbalance between proinflammatory and PRLMs, characterized by excessive LTB4 accumulation and insufficient PRLM levels, such as LXA4 and RvD1

2014 doi: 10.1002/14651858.CD010405

Glutathione plays a key role in fighting free radicals, reducing oxidative stress that can contribute to symptoms in many different chronic conditions, including autoimmune disease
doi: 10.1073/pnas.1820387116 111 LlorenVNakamuraYMeteaCKarstensLMolinsBLinP

In obesity and metabolic dysfunction, NNMT is often overexpressed in adipose tissue, depleting nicotinamide and lowering NAD+ availability [2]

Rubel et al., 2011)
