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[9] Its also prudent to be cautious or avoid NAD+ injections if you have a serious uncontrolled medical condition (for example, end-stage liver or kidney disease or severe heart disease), unless your physician specifically determines its safe

Also auto immune disorders can mess with cycles or do as it did to me

Older adults usually get the same dose as younger people, but need more watching for side effects

This reflects a desire for clear dose-to-volume relationships in metabolic studies

Many people with a deficiency describe deep fatigue, including an "afternoon crash." With infrequent dosing, blood levels can peak and then taper before the next visit

Research further explores its effects on methylation balance, mitochondrial function, and downstream metabolic signaling cascades