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While macrophages and other immune cells can partially clear these ROS, the excessive ROS burden surpasses the clearance capacity of immune cells, allowing residual ROS to further activate necroptosis through positive feedback mechanisms

[DOI] [PubMed] [Google Scholar] 157.Karakuyu NF, zseven A, Akn SE, ama HE, zmen , Cengiz

[DOI] [PMC free article] [PubMed] [Google Scholar] 3.Tong W.H., Pavey C., OHandley R., Vyas A

[DOI] [PubMed] [Google Scholar] [66].Jia H, Chen S, Zhuo R, et al

Thus, validating these findings in larger clinical trials and ensuring the reliability of the results represent significant challenges at present

Kelner MJ, Montoya MA