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These genetic factors exist outside peptide pathways but are central to redox biology

[DOI] [PMC free article] [PubMed] [Google Scholar] 165.Srivastava S.K., Ramana K.V., Bhatnagar A

85 In ganglion cells, it has been published that the increase in intraocular pressure augments TRPV1 expression, which is involved in protecting ganglion cells from apoptosis

A similar potentiation of synaptic strength at glutamatergic synapses on hypocretin/orexin neurons was also seen when mice were sleep deprived for 4 h

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Baseline reductions in structural connectivity also predict progression to poor cognitive outcomes at 3-year follow-up 141 and in PD patients with MCI they predict progression to dementia within 5 years 144 , with interhemispheric frontal and parietal connections being most implicated in cognitive impairment 141,144,145