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Alternatively, accumulated methylmalonate and methylpropionate, precursors of the cobalamin-dependent synthesis of succinyl-CoA, may be incorporated abnormally into branched-chain fatty acids, resulting in abnormal myelination (88)

Vitamin B12 deficiency is common, particularly among people who follow vegetarian or vegan diets, as the vitamin is naturally found only in animal-based foods

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Nasal DPI Peptides for CNS Therapy/Disease Application The IN delivery of proteins and peptides to the CNS allows for the treatment of neurodegenerative diseases such as AD [103], PD [104,105,106], and multiple sclerosis [107,108], among others

An increase in FFA efflux from adipose tissue to liver can result in insulin resistance in the liver and GH is known to antagonise insulin action by this mean [183]

Patient selection should prioritize individuals with conditions where established therapies have proven inadequate or are contraindicated