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The catalase gene promoter and 5'-untranslated region variants lead to altered gene expression and enzyme activity in vitiligo

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In the first two studies, changes in redox and methylation metabolism were reported but because the studies were open-label the changes in these biomarkers were not compared to a placebo group

Indeed, mouse models demonstrate how easily deformative stretch can lead to abnormal calcium influx (Wolf et al., 2001), altered gene expression (Henderson et al., 2017), proinflammatory stimulation, glial network disintegration (Koumlis et al., 2018) and apoptosis of neurons (Liu et al., 1997

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