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By regulating neuroinflammation, oxidative stress, and abnormal protein clearance, they directly or indirectly activate multiple cell death pathways, driving dopaminergic neurodegeneration [238] (Fig

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Human embryonic kidney 293 (HEK293) cells were obtained from the Japanese Collection of Research Bioresources cell bank (Osaka, Japan) and grown in Eagle's minimum essential medium with 10% (v/v) FBS, 100 units/mL penicillin, and 100 mg/mL streptomycin in a humidified atmosphere of 95% air and 5% CO 2 at 37C

Cordyceps sinensis also has a sedative effect on the central nervous system of the body (Zhou et al., 2009)