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For example, the ethanol-inducible CYP2E1, which is located in the centrilobular hepatocytes, effectively catalyzes the centrilobular hepatotoxicity of acetaminophen, carbon tetrachloride, benzene, and nitrosamines

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Falagas ME et al., Crit Care

In the canonical TCA cycle, in addition to pyruvate-derived acetyl-CoA, oxidation of fatty acids or glutamine can be used to produce ATP and intermediates