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In TGF-1-treated HFL1 cells, pretreatment with NRF2-specific inhibitor ML385 (5 M) significantly increased the levels of Gal-3, -SMA and ROS, suggesting that the expression of Gal-3 was regulated by NRF2

10.1016/j.neuroscience.2010.11.046 160 KlecknerI

Intravenous injection of N- nitrosomorpholine caused liver cancer (hepatocellular carcinoma) in rats, and addition of N- nitrosomorpholine to the tank water caused benign and malignant liver tumors (hepatocellular adenoma and carcinoma) in two species of fish (IARC 1978g)

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10.1007/s10142-011-0248-x Funct

Exposure of cultured human hepatocytes to alcohol increased the expression of CYP-2E1 and CYP-3A3/4 up to 6-fold, but the effect appeared to be individually variable [47]