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Levels of Nrf2 and -actin in cytosolic fractions as well as Nrf2 and lamin B1 in nuclear fractions of macrophages were measured using Western blot analysis

In addition, the p62-Keap1-NRF2 32 , ATG5-ATG7-NCOA4 33 , and glutamine metabolic pathways 25 can effectively regulate the formation of intracellular iron ions and ROS and play a regulatory role in ferroptosis (Fig

Supporting this, Lebouvier et al

& Pooga, M

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Both studies showed that when the levels of total glutathione were diminished, the formation of disulphide bonds increased (Chakravarthi & Bulleid, 2004