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Lyophilized (freeze-dried) powders require refrigeration or even freezing before reconstitution

The study addressed two questions: whether the fragment retained activity when delivered enterally rather than parenterally, and whether the effects observed in rodent models translated to human adipose tissue at the cellular level

Free duodenal vitamin B 12 binds to intrinsic factor (IF) [28], with the vitamin B 12 IF complex binding in a calcium-dependent manner to the cubilin receptor on enterocytes in the distal ileum, resulting in receptor-mediated endocytosis and vitamin B 12 absorption

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doi:10.4103/jfmpc.jfmpc_2253_21

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