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Preventive effect of acetyl-L-carnitine on the thermal hypoalgesia in streptozotocin-induced diabetic mice

In fact, preclinical research demonstrates that repeated exposure to several addictive substances evokes a drop in basal concentrations of extracellular glutamate [3,4,5]

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Then, it takes up to 2 days for the substance to reach the highest concentrations in low perfusion tissues, and up to 10 days until it is fully stored in the adipose tissue (Blesching, 2020)