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Clinical trials showed modest fat loss of roughly 2-3 kg over 12 weeks, and the compound was never approved as a pharmaceutical because efficacy did not meet the threshold for drug registration (Heffernan et al., 2001)

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Recommendations for Future Research Despite the promising advancements in weight loss medications like Tesofensine and GLP-1 agonists, numerous research gaps remain

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(13) Researchers have also used inhibitors such as DAPT, which targets the Notch pathway