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Nature 620 (7973), 374380

Since the discovery of the first xCT inhibitor erastin [80], derivatives like imidazole ketone erastin (IKE) was developed to improve solubility meanwhile introducing lysine-reactive ketone as a covalent warhead, thereby achieving nanomolar IC 50 [81,82]

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PMID: 14673993 Fraternale A, Paoletti MF, Casabianca A, Nencioni L, Garaci E, Palamara AT, Magnani M

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