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In addition to their lack of efficiency, oral supplements can sometimes cause gastrointestinal distress, such as nausea or upset stomach

[DOI] [PMC free article] [PubMed] [Google Scholar] [132].Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, Miyazaki Y, Kohane I, Costello M, Saccone R, Landaker EJ, Goldfine AB, Mun E, DeFronzo R, Finlayson J, Kahn CR, Mandarino LJ

Effective doses appear to start at 100 200 mcg/day.[ref][ref] The RDA for folate from food is 400 mcg/day

10.1038/234466a0 47 LouxS

doi: 10.3390/v13101966 170
