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Further, an LPS administration model of systemic inflammation in sepsis in conjunction with convulsant PTZ treatment in mice increased seizure susceptibility, which was attenuated with NOX2 genetic ablation and inhibition ( Epileptic encephalopathies and genetic epilepsies such as West, Lennox-Gastaut, Dravet, Lafora, and Leigh syndromes have additionally shown evidence of gliosis and neuroinflammation in humans (You et al., 2009

General symptoms of thiamine deficiency include confusion, psychomotor retardation, impaired memory and cognitive function, and ataxia (36, 40)

Tumor heterogeneity further complicates this landscape, as the extent of GSH dependency varies across tumor types, metabolic states, and microenvironments, with poorly defined consequences for therapeutic response

Folate deficiency reduces the GPI-anchored folate-binding protein in rat renal tubules

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