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Further MR-Egger analysis validated the lack of heterogeneity ( p = 0.564) and pleiotropy ( p = 0.800)

Alternativen: 3 mL Wasser ~16,7 mg/mL (10 Units 1,67 mg) oder 5 mL Wasser 10 mg/mL (10 Units = 1 mg, klassische Variante)

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Free Radic Biol Med 67:366376

A basket study that implements multiple independent two-stage designs will have a much higher false-positive rate than a typical phase II study and therefore a higher likelihood of being declared effective in at least one basket when in fact the drug is truly ineffective [132]

Sample sizes were determined based on a power analysis using = 0.05, = 0.2, and effect sizes of 20% based on our experience with murine salivary gland cell hydrogel encapsulations and in vivo irradiation studies