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However, increased lactate in inflamed tissues could be a key point of T cell suppression, in which environmental lactate is metabolized to pyruvate, accompanied by NAD + reduction to NADH (Fig

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The KP may mediate the link between systemic inflammation and cognitive decline through neuroactive metabolites, which are formed under inflammatory conditions [5]

Academic, San Diego, pp 115 Rabb H (2002) The T cell as a bridge between innate and adaptive immune systems: implications for the kidney

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When oxidative damage accumulates, its been linked to virtually every chronic condition imaginable - from cardiovascular disease and diabetes to neurodegeneration, infertility, and cancer (Sies & Jones, 2020)