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Its also central to several biochemical pathways that cancer cells use to build new cell parts

10.1212/01.WNL.0000284604.61160.2d 155

Tehlivets O, Malanovic N, Visram M, Pavkov-Keller T, Keller W

Springer, New York, pp 733 Zhou JM, Trifa Y, Silva H, Pontier D, Lam E, Shah J, Klessig DF (2000) NPR1 differentially interacts with members of the TGA/OBF family of transcription factors that bind an element of the PR-1 gene required for induction by salicylic acid

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For example, cellular senescence, classified as an antagonistic/secondary hallmark of aging, results as a consequence of persistent DNA and/or proteomic damage (primary hallmarks) that drives integrative hallmarks such as chronic inflammation and altered intracellular signaling, which further perpetuate other aging hallmarks
