glutathione inhibitor bso Lung and oxidative stress: implications in cigarette smoke-induced airway disease | American Journal of Physiology-Lung Cellular and Molecular Physiology L -Buthionine-sulfoximine = 97 TLC

doi:10.1093/ecam/nem040 References are provided for educational context

Andreani, C., Bartolacci, C

Determination of N-carbamylglutamate in feeds and animal products by high performance liquid chromatography tandem mass spectrometry

Giladi N, Meer J, Honigman S

Within the mitochondria, leaking electrons resulting in ROS production occurs predominantly at complexes I and III of the ETS in a resting state, though superoxide may also be produced by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase ( Figure 1 While the antioxidant capabilities of Se have been a popular and integral subject of investigation, there are a vast array of additional biological roles of Se, some which may be extensions of antioxidant activity but others which are unrelated to Se's redox role that may be overlooked

As a result, glycolytic pyruvate is not converted to acetyl-CoA and NADH, decreasing the NADH flux to the electron transport chain (ETC) and production of ROS