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There have also been studies demonstrating the key roles of other amino acids in the regulation of T cells ( in vitro treatment with SAM or MTA promoted the expression of exhaustion marks, inhibited IFN- expression, and caused a closed chromatin structure in human CD8+ T cells ( MAT2A knockout protected tumor-infiltrating CD8+ T cells from exhaustion in a syngeneic mouse tumor model ( Figure 2 Perspective on methionine metabolism in T cell immunotherapy Improving cancer immunotherapy by targeting the methionine cycle of T cells is an area that remains unexplored

doi:10.1111/j.1530-0277.2008.00833.x, ACER833 [pii] Winterbourn CC (2013) The biological chemistry of hydrogen peroxide

J Extracell Vesicles (2016) 5:29642

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